In a presentation titled “Building Multispecifics from in vivo Derived Antibody Domains and Alternative Scaffolds,” Yasmina Abdiche, Ph.D., Vice President of Exploratory Research, provided an overview of building multispecifics ranging from traditional CD3 T cell engagers to next-generation NK cell engagers, facilitated by emerging targets such as NKp46.

“OmniAb’s technologies offer significant advantages in multispecifics, including naturally optimized human sequence immune repertoires across multiple host species, a variety of antibody modalities to support novel molecular formats, and artificial intelligence (AI)-augmented single B cell workflows for deep repertoire mining,” said Matt Foehr, Chief Executive Officer of OmniAb. “We have a strong track record of delivering candidates which lead to clinical-stage and approved bispecifics, where on-target specificity, developability, tunable affinity and broad epitope coverage are all important elements. Leveraging this foundation, our platform offers versatile multi-modality options, providing our partners with the flexibility to execute their campaigns effectively.”

“This case study presentation demonstrates how we discovered developable anti-NKp46 binders with broad epitope coverage and affinities, serving as building blocks for NK cell engager multispecifics. We enhanced high-throughput phenotypic screening with AI-guided next-generation sequencing workflow to explore the vast sequence space and identify high-quality leads, thereby avoiding extensive ex vivo engineering,” added Dr. Abdiche.

At AETC the Company also highlighted OmniHub^™, a high-dimensional unified bioinformatics portal, in a presentation titled “Design and Implementation of OmniHub^™, A Platform for Bioinformatics Tools Facilitating Antibody Discovery Workflows,” by Swetha Garimalla, Ph.D., Director of Computational Immunology. OmniHub^™ is part of OmniAb’s ongoing commitment to enhancing the partner experience with its technologies and services. OmniHub^™ enables scalable and secure data transfer, advanced visualization and comprehensive tool access.