The poster will highlight the scientific rationale for combining anti-HER3 antibody HMBD-001 with EGFR inhibition and chemotherapy to improve treatment outcomes in squamous non-small cell lung cancer (sqNSCLC).

"Genetic alterations due to environmental insults are frequently observed in squamous cell carcinomas. Prominently, these alterations cause aberrant HER3 and EGFR signaling, leading to proliferation and survival of these cancer cells," said Kwek Kon Yew, BM BCh, DPhil, Senior Vice President of Clinical Development, Hummingbird Bioscience. "Based on our preclinical studies, we believe that a biomarker-defined patient population with sqNSCLC will benefit clinically from the blockade of these aberrant signals using HMBD-001 and cetuximab in combination with standard of care chemotherapy."

Hummingbird Bioscience has recently initiated Phase Ib trials in Australia to evaluate the activity of HMBD-001 in patients with sqNSCLC, as well as in patients with genetic aberrations in HER3 signaling.

Poster Details  

Title: Combining Anti-HER3 Antibody, HMBD-001, with EGFR Inhibition and Chemotherapy may Improve Treatment Outcomes in SqNSCLC
Session: P1.12 Tumor Biology – Translational Biology - Translational Therapeutics
Poster number: P1.12-05
Date and Time: Sunday, September 10, 2023 at 5:30 PM UTC +8
Location: Exhibit Hall

#WCLC23