Elabscience^® Bionovation Inc. ("Elabscience^®" or "the Company")  announced the launch of its self-developed PolyHRP-Streptavidin conjugate, a signal amplification reagent designed to improve enzyme-linked immunosorbent assay (ELISA) sensitivity for low-abundance biomarker detection. Using proprietary covalent polymerization technology, the reagent creates a one-to-many amplification structure that strengthens detection signals while maintaining low background interference.

Elabscience^® developed its PolyHRP-Streptavidin conjugate to address a common ELISA challenge in which very low biomarker concentrations can make it difficult to increase signal output without also raising background noise. The product is built on a proprietary covalent coupling technique designed to create a more efficient amplification structure than traditional Streptavidin-HRP conjugates. In this process, a large number of highly active HRP enzymes are first polymerized to form a PolyHRP backbone, which is then conjugated to streptavidin. This one-to-many architecture increases the enzyme-to-protein ratio and enables cascade signal amplification which helps to improve assay sensitivity in low-abundance biomarker detection.

Dr. Yang Fei, General Manager of Elabscience^®, commented: "Sensitivity and stability are critical requirements in ELISA reagent development, especially when researchers are working with low-abundance targets. With our self-developed PolyHRP-Streptavidin conjugate, we aim to provide researchers and assay developers with a reliable signal amplification tool that supports stronger detection performance, lower background interference and long-term reagent stability."

Validation data showed strong performance across several key measures. SEC-HPLC analysis of three independent batches demonstrated an approximately 90% product recovery rate, with a peak area coefficient of variation of 2.9%, indicating high batch-to-batch consistency. Nanoparticle tracking analysis also showed a narrow particle size distribution centered at about 155 nm which supports the uniformity of the PolyHRP-Streptavidin polymer structure.

In internal performance testing, Elabscience^® PolyHRP-Streptavidin delivered strong signal intensity while maintaining low background signal. Accelerated stability testing at 37°C showed over 90% remaining activity after 11 days, demonstrating strong reagent stability under accelerated conditions. The product is also designed for broad compatibility across standard ELISA, high-sensitivity ELISA and competitive ELISA workflows.

The launch introduces Elabscience^® PolyHRP-Streptavidin conjugate, Catalog No. E-ELIR-020, as a specialized ELISA accessory reagent within the Company's signal amplification portfolio. It is available in a 50 μL trial size, a 250 μL catalog format, and custom volumes above 1 mL. The product is stored at -20°C and has a shelf life of two years. Elabscience^® also plans to introduce a ready-to-use PolyHRP-Streptavidin detection reagent to further support routine and high-throughput ELISA applications.