Beckman Coulter Life Sciences, a Danaher company and global leader in laboratory automation and innovation, has announced the commercial release of the Echo 650 Plus Series acoustic liquid handlers. The latest generation platform introduces enhanced electronics architecture, next generation acoustic performance, and significantly improved energy efficiency to strengthen reliability, reduce operational costs, and advance sustainability objectives for high throughput laboratories.

The Echo 650 Plus Series has been engineered to deliver measurable gains in acoustic liquid handling workflows widely used across drug discovery and life sciences research applications.

“With the Echo 650 Plus Series, we focused on delivering measurable performance improvements that matter to our customers—greater reliability, lower operating costs, and smarter, real time system intelligence,” said Sudarshana Seshadri, Vice President Product Management, Beckman Coulter Life Sciences. “These upgrades empower scientists to scale acoustic liquid handling with confidence, efficiency, and precision across demanding workflows.”

At the core of the new platform is a next generation transducer featuring a durable titanium lens designed to simplify instrument power down procedures while enabling reliable and rapid recovery during operations. The upgraded transducer stability also removes the need for routine focus calibration tracking and adjustments, helping laboratories minimise manual intervention while maximising system uptime.

The Echo 650 Plus Series also incorporates a redesigned electronics architecture that improves real time computational capability, manufacturability, and overall system reliability. These combined enhancements contribute to a 54% reduction in power consumption compared to previous generation Echo systems, supporting lower operating costs and broader laboratory sustainability initiatives.

The new instruments further introduce Dynamic Fluid Analysis 2 (DFA2), an advanced machine learning enabled capability that leverages real time acoustic feedback to optimise Acoustic Droplet Ejection performance. DFA2 dynamically evaluates fluid surface responses prior to each droplet transfer and automatically selects the optimal calibration settings for every well. This adaptive approach improves fluid measurement accuracy, transfer reliability, and long term consistency across diverse sample types and assay conditions.

Built on commercially proven acoustic liquid handling technology, the Echo 650 Plus Series is designed to support increasingly complex and high throughput drug discovery environments, where precision, scalability, and operational efficiency remain critical priorities.