-  WuXia^ADCC PLUS^TM is designed to meet the market need for improved antibody therapeutic efficacy by producing afucosylated antibodies with the ability to increase antibody-dependent cell-mediated cytotoxicity (ADCC), providing diverse bioprocessing solutions for global clients

-  WuXia^ADCC PLUS^TM is derived from WuXi Biologics' highly-vetted WuXia^TM cell line platform

ADCC is recognized as a crucial mechanism underlying targeted antibody-based immunotherapy approaches. The development of novel cancer therapies entails designing and engineering antibodies with increased ability to heighten the ADCC response, which is known to improve therapeutic efficacy and patient outcomes.

Removal of fucose on the N-glycosylation site is an efficient and cost-effective way to enhance ADCC activity and increase the potency of antibody-based immunotherapies. To meet growing global demand for the production of afucosylated antibodies, the WuXia^ADCC PLUS^TM cell line was derived from the WuXi Biologics' highly-vetted WuXia^TM cell line. The WuXia^ADCC PLUS^TM cell line is compatible with the WuXia^TM platform process, which enables the stable production of the afucosylated antibodies at various scales for clinical and commercial manufacturing.

Dr. Chris Chen, CEO of WuXi Biologics, commented, "We are pleased to launch WuXia^ADCC PLUS^TM to provide a new bioprocessing solution for our global clients developing novel antibody therapies. WuXi Biologics' continual launch of new technology platforms comes from our drive to push boundaries and foster innovation – all with the goal of enabling our global partners to bring more high-quality and affordable biologics to patients worldwide."