- Insighta is a 50/50 Joint Venture by Prenetics and Professor Dennis Lo.

- Insighta is powered by technology developed by the Centre for Novostics which is supported by the InnoHK Initiative of the Innovation and Technology Commission of the Hong Kong SAR Government.

- By 2030, the early cancer detection screening opportunity is estimated to be US$6bn in Asia on an annual basis.¹

• Prof. Dennis Lo, is the Li Ka Shing Professor of Medicine of the Chinese University of Hong Kong (CUHK) and the Scientific Director of the Centre for Novostics.

Transaction Terms - Prenetics will receive a 50% equity stake, while Prof. Lo's party will also receive a 50% equity stake. The joint venture will be governed by a six-person board of directors composed of three directors from each side, with Prof. Lo as the Chairman and Danny Yeung as the CEO. The US$200m transaction makes it the largest private life sciences deal in Hong Kong history and one of the largest in the region.

Prof. Lo will contribute:

World-Class Science – Prof. Lo, renowned for his ground-breaking work in non-invasive prenatal testing (NIPT) and in liquid biopsy, has been bestowed with some of the highest distinctions in life sciences. These accolades include his induction as a Fellow of the Royal Society in 2011, recipient of the esteemed Royal Medal and Breakthrough Prize in 2021, and, most recently, the distinguished Lasker Award in 2022².

Prof. Lo, as the Associate Dean (Research) of the Faculty of Medicine at the Chinese University of Hong Kong, consistently demonstrates outstanding academic leadership. His influence extends far beyond the realm of academia, however. Prof. Lo's ground-breaking NIPT technology, which he introduced to the world in 2011, now provides standard of care prenatal screening for over 10 million expectant mothers annually across more than 90 countries. Given the significant global market value of the NIPT technology, currently standing at US$7.3bn, its increasing application is anticipated to drive it to an estimated US$13.1bn by 2027³.

"FRAGMA", a new breakthrough technology in which Prof. Lo published in 2022^4. will be the technology utilized for multi-cancer early detection screening for Insighta.

Prof. Lo's entrepreneurial success is marked by his co-founding of Cirina, a company acquired by Grail in 2017 for US$300m. Grail itself was subsequently bought by Illumina for a remarkable US$7.1bn, further highlighting Prof. Lo's considerable impact in the life sciences industry.

Prenetics will contribute:

Robust Capital – Prenetics will provide consideration of US$100m, with US$80m in cash and US$20m in Prenetics stock. The significant outlay by Prenetics demonstrates a shared belief in Insighta's potential and will be directly utilized to fast-track clinical trials and commercialization of the breakthrough early cancer detection technology.

Strong Management and Commercialization – Danny Yeung, esteemed serial entrepreneur and the dynamic force behind Prenetics, will extend his leadership role as CEO to Insighta. Danny's proven track record positions him perfectly for steering Insighta's journey ahead.

Danny Yeung, Chief Executive Officer of Prenetics and Insighta said, "I am absolutely thrilled to embark on this Joint Venture alongside Prof. Dennis Lo, a figure of immense reverence in the scientific community. His pioneering work in genomics has already transformed millions of lives around the globe. With Insighta, we are presented with a once in a lifetime opportunity. The potential of our Presight test is immense, potentially influencing the health of 1 billion individuals in Asia. Our primary focus for the initial launch will be in Mainland China, Hong Kong and other parts of Asia. On a global scale, we intend to forge alliances with healthcare institutions and forward-thinking governments that align with our vision – a commitment to save lives through the power of early cancer detection. Given the scale of our mission to combat cancer, we are enthusiastically open to collaborations with researchers and partners worldwide. We wholeheartedly welcome your contributions and insights."

Prof. Lo said, "I am genuinely exhilarated to be at the forefront of such a ground-breaking new technology. Joining forces with Danny Yeung and Prenetics is particularly inspiring - a joint venture that not only ensures robust capital resources, strong management but also a mutual vision of global health transformation. We are driven by the profound potential to save countless lives, and together, we will make a significant stride towards a healthier future for all."

Prof. Lo further stated "Insighta is dedicated to introducing a breakthrough technology, "FRAGMA". The science behind Presight holds immense potential for multi-cancer early detection. Epigenetics studies the modifications of DNA that affect its behaviour without changing the DNA sequence. Fragmentation patterns of plasma DNA can be used as an epigenetics-based cancer test with high accuracy and a simple workflow. Another key distinguishing hallmark of Presight is its cost-effectiveness. This innovation doesn't merely represent a significant leap in cancer detection—it has the potential to transform millions of lives and change the trajectory of cancer prognosis, offering hope where it was once scarce."

Danny Yeung further said "We are mindful that cost is a vital determinant in the viability of any breakthrough science and Presight has been engineered with cost as a critical factor. With a target price of less than US$200 per test, Insighta exemplifies our commitment to advancing science for the betterment of global health. Our objective is to transform early cancer detection from a luxury to a universally accessible necessity."

Market Opportunity

Cancer is a global health challenge causing 10 million deaths each year worldwide, including 6 million fatalities in Asia alone⁵. The key to enhancing survival rates lies in early detection, yet unfortunately, most cancers are diagnosed in their advanced stages when treatment options are limited and prognoses are often dire. Despite the importance of screening, the current globally-accepted guidelines only encompass five specific types of cancer. Strikingly, there are no recommended early detection screenings for cancers accounting for nearly 71% of global cancer-related deaths⁶.

Insighta's first breakthrough test, Presight, is set to begin a multi-country 5000-patient clinical trial in early 2024. The initial Presight tests will be focused on liver and lung cancer with it first being made commercially available in Mainland China and Hong Kong in 2025.  Liver and lung cancers are the first and second most lethal forms of cancer in Mainland China and pose a significant health threat across all of Asia. In 2027, Insighta plans to launch Presight One, a multi-cancer early detection test capable of detecting more than 10+ different cancers.

Considering that the median age for cancer diagnosis is 66 years, it is clear that individuals aged 40 and above are the most likely to reap the benefits of early cancer detection⁷. This demographic represents a staggering 2.03 billion people globally, with Asia contributing to a substantial 1.22 billion of this population. These statistics underscore the urgent and pressing need for innovative early cancer detection solutions. By the year 2030, the demand for early detection cancer screenings could potentially translate into 30 million tests in Asia, annually. This indicates not only a promising advance in healthcare but also a substantial market opportunity, which Prenetics estimates at US$6 billion. Insighta's focus underscores our mission of saving lives through early cancer detection, and we see this forecast as a testament to the game-changing impact of our cutting-edge technology.

Danny Yeung concluded, "This represents a transformative milestone for Prenetics, enabling us to enhance life's quality through cutting-edge scientific innovations. From prevention (CircleDNA) and early detection (Insighta) to treatment (ACT), our innovative approach promises to significantly raise the bar in healthcare."