18 August 2021 | Wednesday | News
Biotechgate Digital Partnering is an event that provides a platform for business development in the field of licensing and collaboration. 14 out of the top 20 big pharma companies and more than 2,700 companies from over 60 countries have participated in the past events.
During the event, PharmAbcine's business development team will hold one-on-one virtual meetings with global pharmas, biotechs, and healthcare companies to discuss potential licensing deals or collaborations for the Company's main pipelines such as olinvacimab, PMC-403, and PMC-309.
Olinvacimab, an anti-VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) fully human antibody, is the Company's leading pipeline and is undergoing multiple global clinical trials. Currently, a Phase II olinvacimab mono study for bevacizumab-nonresponding rGBM (recurrent glioblastoma multiforme) patients is taking place at multiple sites in both US and Australia. Also, two Phase Ib olinvacimab and pembrolizumab combo trials in mTNBC and rGBM are still ongoing in Australia.
PMC-403 is a novel TIE2-activating fully human antibody designed to stabilize and repair damaged blood vessels in a variety of diseases. PMC-403 is currently in development for treating AMD (Age-related Macular Degeneration), DME (Diabetic Macular Edema), and DR (Diabetic Retinopathy) which are common abnormal vascular-related eye diseases. The Company expects PMC-403 to enter global clinical trials for both ophthalmology and oncology in 2022.
PMC-309 is a novel anti-VISTA (V-domain Ig Suppressor of T cell Activation) antagonizing antibody in development for the treatment of various tumor types. VISTA plays a pivotal role in maintaining the immunosuppressive environment around the tumor cells and is expressed primarily on MDSC (Myeloid-Derived Suppressor Cells) and Tregs (regulatory T cells). Blocking VISTA pathways activates T cells' immune responses and leads to better anti-tumor effects. PMC-309 is expected to enter a global clinical trial in 2022.