• The Phase I trial of ENERGI-F705PD tablet was a randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability, and pharmacokinetics of the investigational drug in 24 healthy subjects.
• The results confirmed the favorable safety and tolerability profile of ENERGI-F705PD and successfully validated its sustained-release oral formulation.
• Energenesis plans to advance ENERGI-F705PD into a Phase II trial.

Energenesis Biomedical Co., Ltd. (TWSE: 6657), a clinical-stage biotechnology company focused on cellular energy restoration therapeutics,  announced the successful completion of its Phase I clinical trial for ENERGI-F705PD, an oral investigational drug candidate for Parkinson's disease (PD). The Phase I study demonstrated favorable safety and tolerability in healthy volunteers, marking a significant milestone in the development of ENERGI-F705PD and reaffirming its potential as a disease-modifying therapy that targets intracellular alpha-synuclein aggregation. Energenesis Biomedical plans to submit a Phase II clinical trial application in 2025 to further evaluate the therapeutic efficacy of ENERGI-F705PD in patients with Parkinson's disease.

"Current treatments for Parkinson's disease primarily target symptoms, while ENERGI-F705PD represents a novel therapeutic strategy with disease-modifying potential," said Dr. Han-Min Chen, CEO & Founder of Energenesis Biomedical. "ENERGI-F705PD targets Parkinson's disease by restoring cellular energy ATP levels, preventing cellular alpha-synuclein aggregation, and decreasing ROS levels for neuroprotection. This multi-pronged approach may significantly slow disease progression. The encouraging results from our Phase I trial bring us one step closer to delivering a meaningful treatment option for PD patients worldwide."