"The full approval of our prototype vaccine will enable us to file for approval of our updated protein-based non-mRNA COVID-19 vaccine in the coming weeks," said John C. Jacobs, President and Chief Executive Officer, Novavax. "We continue to work closely with HSA to ensure a protein-based vaccine is part of the portfolio for Singaporeans to protect themselves against COVID-19."

For the 2023-2024 vaccination season, Novavax has developed an updated COVID-19 vaccine which has been authorized for use in the U.S. The updated vaccine induces neutralizing antibody responses against currently circulating variants XBB.1.5, XBB.1.16, XBB.2.3, BA.2.86, EG.5.1, FL.1.5.1 and XBB.1.16.6. Additional non-clinical data demonstrated that Novavax's vaccine induced CD4+ polyfunctional cellular (T-cell) responses against EG.5.1 and XBB.1.16.6. These data indicate Novavax's vaccine can stimulate both arms of the immune system and may induce a broad response against currently circulating variants.^1,2

In clinical trials, the most common adverse reactions associated with Novavax's prototype COVID-19 vaccine (NVX-CoV2373) included headache, nausea or vomiting, muscle pain, joint pain, injection site tenderness, injection site pain, fatigue and malaise.