CLIMB is a US based, randomized, double-blind, placebo-controlled Phase 2 study to evaluate the safety, tolerability and efficacy of ARINA-1 in participants with bronchiectasis. Efficacy endpoints in this trial include quality of life, sputum rheological markers, blood inflammatory markers and other exploratory clinical markers.

"We are pleased to report that we have completed adult patient enrollment in the CLIMB study for bronchiectasis. This is a great milestone for our company and for people living with bronchiectasis," said Dan Copeland, Chief Executive Officer of Renovion. "CLIMB will provide data regarding ARINA-1 as a first line therapy for bronchiectasis, a serious pulmonary disease that today has no approved treatments. The enthusiasm of the treating community and patient interest in the trial reflect the significant need for a therapy that can help these patients reduce symptoms and improve quality of life. We see ARINA-1 as a potential first line therapy to address the significant impact of bronchiectasis symptoms in the lives of patients, and we look forward to sharing the trial results later this quarter.”

The CLIMB study was conducted at 10 sites in the United States. Renovion is developing ARINA-1 to break the cycle of mucus, inflammation and infection in chronic inflammatory lung diseases by delivering ARINA-1 directly to the lungs of patients. Based on experience in patients to date, ARINA-1 is well positioned to be a first line therapy for patients that need a fast onset of action and an attractive safety profile.