03 February 2023 | Friday | News
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Combined with other clinical risk factors the test provides a comprehensive risk assessment in a simple saliva test.
Globally, there are more than 2.26 million cases of Breast Cancer2 and 313,000 cases of Ovarian Cancer3 diagnosed annually. In the USA there are 297,790 new cases of invasive breast cancer that are diagnosed annually4 and 19,880 women diagnosed with ovarian cancer5.
Currently women are under-screened and underdiagnosed for risk of hereditary breast and ovarian cancer syndrome (HBOC) based on their clinical criteria. There is considerable evidence that these criteria do not capture all women who are HBOC carriers. One recent general population screen among more than 6,000 women found that of 38 HBOC carriers identified nearly half would not have qualified for HBOC testing based on clinical criteria and their elevated risk of cancer would not have been identified.
GTG’s comprehensive risk assessment for both cancers inform women of their risk profile and as a result, the opportunity to take proactive actions to increase screening and lessen their risk of developing these diseases. The risk assessment is performed from a single saliva sample and a brief questionnaire.
Implementation of the test as a population-based genetic screening for Breast and Ovarian is supported by GTG’s independently developed Budget Impact Model (‘BIM’) providing a strong health and economic case for payers and insurers in the U.S. Supplemental screening in a subpopulation of women identified as at-risk by geneType can lead to an increase in early-stage, screen-detected cancers, which in turn is associated with high 5-year survival rates 99%6 and 93%7 for breast and ovarian, respectively.
GTG’s CEO, Simon Morriss, commented: “GTG believes this Comprehensive Risk Test for Breast and Ovarian Cancer is one of our most important and significant contributions to the advancement of population-based genetic testing. We are moving beyond rare cancer-susceptibility genetics. We can look for the needle in the haystack, but we are also able to look at the haystack itself. Our non-invasive risk assessment test will address cancer risk at a population health level.”