Synopsis
Driven by the need to support the production of high-intensity cell cultures of higher volumetric scales, the demand for performance efficiency at the harvest step of bioproduction has grown.
Download whitepaper: Finding an optimal harvest solution by considering both cost and sustainability
This paper evaluated two technologies for direct comparison.
- Depth filtration - the most common technique utilized in the harvest market
- Single-use centrifugation - A technology that has been leveraged primarily at the small to mid-volume range
Stainless steel centrifugation has been used at large volumes, but this technology is different from single-use in that it requires steam-in-place (SIP) clean-in-place (CIP) systems and is always accompanied by extensive validation work.
Key features of the Thermo Scientific™ DynaSpin™ Single-Use Centrifuge
- Closed-system bioprocessing with safe, robust, and ergonomic operation
- Significant reduction in depth filters, depth filter hardware, WFI, buffer, and waste requirements
- Plug-and-play automation functionalities allows for increased process monitoring and leads to increased quality
- Simple installation and operations