Single-use technologies (SUTs) have revolutionized drug and vaccine manufacturing with their ease of use, increased capacity, reduced contamination risk, and elimination of cleaning requirements. Cable ties and tubing retention devices are essential components in the single-use bioproduction process. However, traditional cable ties have limitations such as potential leaks, uneven compression, sharp edges, attachment variability, and particulate generation. Considering these concerns, are cable ties a reliable long-term solution for tubing retention?